|
KMID : 0614020090240010024
|
|
Journal of Pharmaceutical Sciences (C.N.U.)
2009 Volume.24 No. 1 p.24 ~ p.36
|
|
|
Recent Trends in Development of Analytical Methods for the Quantification of Statins in Biological Fluids
|
|
Woo Kyung-Sik
Park Jeong-Sook
|
|
|
Abstract
|
|
|
|
Statins are reversible inhibitors of S-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase, widely used for the treatment of hyperlipidemia as well as atherosclerosis. Recently, various brands of cholesterol lowering statin drugs have been frequently prescribed and dispensed to the patients for reducing morbidity and mortality related to coronary heart disease. Therefore, demands for development of reliable and sensitive analytical methods for statins in biological fluid have been increased to monitor the plasma concentrations of drugs. A lot of chromatographic-mass spectrometric methods for the quantification of presently available seven statins such as atorvastatin, simvastatin, lovastatin, pravastatin, fluvastatin, rosuvastatin, and pitavastatin have already been published. Of analytical methods, high performance liquid chromatography (HPLC) with tandem mass spectrometry (MS／MS) is the analytical technique of choice for the quantification of statins in biological samples. This review covers most of the analytical method used for quantification of statins, which are applied for plasma sample and suitable for therapeutic drug monitoring.
|
|
|
KEYWORD
|
|
|
stain, analytical method, biological fluid, LC-MS/MS, mass spectrometry, chromatography
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|